InauhzinisaninhibitorofSIRT1thatactivatesp53;italsoinhibitsinosinemonophosphatedehydrogenase(IMPDH).Inauhzinexhibitsanticancerchemotherapeuticactivities,inducingapoptosisandsuppressingcellgrowthinnon-smallcelllungcancer(NSCLC)andcoloncancercells.Thiscompoundalsoinducessenescenceinandrepressestumorgrowthincellularandanimalmodelsoflungcancerandcoloncarcinoma.
| CasNo. | 309271-94-1 |
|---|---|
| Purity | ≥98% |
| Formula | C25H19N5OS2 |
| FormulaWt. | 469.58 |
| IUPACName | 1-(10H-Phenothiazin-10-yl)-2-(5H-[1,2,4]triazino[5,6-b]indol-3-ylsulfanyl)-1-butanone |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | I5203InfoSheetPDF |
|---|
ZhangQ,ZhouX,WuR,etal.TheroleofIMPdehydrogenase2inInauhzin-inducedribosomalstress.Elife.2014Oct27;3.PMID:25347121.
ZhangY,ZhangQ,ZengSX,etal.Inauhzinsensitizesp53-dependentcytotoxicityandtumorsuppressionofchemotherapeuticagents.Neoplasia.2013May;15(5):523-34.PMID:23633924.
LKT Labs
LKT实验室是一家专注于小分子的合成、纯化和分离的生化供应公司，用于研究应用。它的产品系列展示了已知的生物活性，在广泛的研究领域，特别是癌症和神经科学中得到了广泛的应用。这些产品包括蛋白激酶抑制剂、离子通道调节剂和激活剂。
LKT Laboratories is a biochemical supply company focused on the synthesis, purification, and isolation of small molecules for research applications. Its range of products exhibit known biological activities that have found uses in a wide array of research fields, especially cancer and neuroscience. These products include protein kinase inhibitors, ion channel modulators, and activators.
|
品牌 |
货号 |
名称 |
规格 |
|
LKT Labs |
444912-48-5 |
(2-iodo-5-nitrophenyl)-[1-[(1-methylpiperidin-2-yl)methyl]indol-3-yl]methanone |
1mg 5mg 25mg |
|
LKT Labs |
294646-77-8 |
(R)-CR8 |
1mg 5mg |
|
LKT Labs |
2377-31-3 |
(Z)-1,-BIS(2-METHOXY-5-(TRIFLUOROMETHYL)PHENYL)DIAZENE OXIDE |
1mg 5mg 25mg |
