Description
NVP-TAE684isaninhibitorofanaplasticlymphomakinase(ALK),c-Fes,andLRRK2thatexhibitsanticancerchemotherapeuticactivity.NVP-TAE684inducesapoptosisinandinhibitsgrowthofdiffuselargeB-celllymphomacells;inanimalmodels,itinducestumorregression.NVP-TAE684alsoinducescellcyclearrestandapoptosisinanimalmodelsofanaplasticlarge-celllymphoma,preventinglymphomagenesisandinducingregression.
References
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