LKT/U03B2-TOCOTRIENOL/T5609/5 mg,LKT Labs,,LKT Labs,lktlabs,+,,Array.Array.Array蚂蚁淘厂家直采.

ProductIDT5609

CasNo.490-23-3

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

Tocotrienolscontainanarenering,achromanolring,andanisoprenoidtail;alltocotrienolcompoundscontainamethylgrouponC8ofthearenering.β-Tocotrienolcontainsoneadditionalmethylgrouponthearenering,positionedparatoC8.TocotrienolsaremembersofthevitaminEfamily,typicallyfoundinvegetableoils,nuts,andgrains.Tocotrienolsexhibitstrongantioxidativeactivityaswellasanti-angiogenic,anticancer,andanti-hyperlipidemicqualities.Tocopherols,commonsubstituentsofover-the-countervitaminEsupplements,interferewithtocotrienolactivityandshowweakerantioxidativeeffects.TocotrienolsexhibitsignificantrADIcalrecyclingABIlitiesincellularmodelsoflipidperoxidationandoxidativedamageandsuppressHMG-CoAreductaseactivity.Invitro,thesecompoundsinduceapoptosisthroughinhibitionofId1,EGFR,andNF-κB;theyalsoinhibitvesselformationandproliferationinaorticendothelialcells.

ProductInfo

CasNo.	490-23-3
Purity	≥98%
Formula	C₂₈H₄₂O₂
FormulaWt.	410.63
IUPACName	(2R)-2,5,8-trimethyl-2-[(3E,7E)-4,8,12-trimethyltrideca-3,7,11-trienyl]-3,4-dihydrochromen-6-ol
Synonym	beta-tocotrienol
Solubility	Solubleinethanol,hexanes,DMSO,DMF
Appearance	yellowliquid

ShippingandStorage

StoreTemp	-20°C
ShipTemp	Ambient

Downloads

MSDS	T5609MSDSPDF
InfoSheet	T5609InfoSheetPDF

References

YapWN,ChangPN,HanHY,etal.Gamma-tocotrienolsuppressesprostatecancercellproliferationandinvasionthroughmultiple-signallingpathways.BrJCancer.2008Dec2;99(11):1832-41.PMID:19002171.

SenCK,KhannaS,RoyS.Tocotrienols:VitaminEbeyondtocopherols.LifeSci.2006Mar27;78(18):2088-98.PMID:16458936.

InokuchiH,HirokaneH,TsuzukiT,etal.Anti-angiogenicactivityoftocotrienol.BiosciBiotechnolBiochem.2003Jul;67(7):1623-7.PMID:12913317.

ParkerRA,PearceBC,ClarkRW,etal.Tocotrienolsregulatecholesterolproductioninmammaliancellsbypost-transcriptionalsuppressionof3-hydroxy-3-methylglutaryl-coenzymeAreductase.JBiolChem.1993May25;268(15):11230-8.PMID:8388388.

SerbinovaE,KaganV,HanD,etal.Freeradicalrecyclingandintramembranemobilityintheantioxidantpropertiesofalpha-tocopherolandalpha-tocotrienol.FreeRadicBiolMed.1991;10(5):263-75.PMID:1649783.

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