ImatinibisananticancerchemotherapeuticcompoundthatinhibitsAbl,c-Kit,andPDGFR;itisusedclinicallytotreatPhiladelphiachromosome-positivechronicmyelogenousleukemia(CML)andacutelymphocyticleukemia(ALL).Incellularassays,imatinibaccelerateserythroblastdifferentiationandinhibitsmelanogenesis.
| CasNo. | 220127-57-1 |
|---|---|
| Purity | ≥98% |
| Formula | C29H31N7O•CH3SO3H |
| FormulaWt. | 589.718 |
| ChemicalName | methanesulfonicacid;4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide |
| IUPACName | methanesulfonicacid;4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide |
| MeltingPoint | 226C |
| Solubility | Ethanol(0.2mg/ml),DMSO(10mg/ml),DimethylFormamide,PBS(2mg/mL) |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | I4802MSDSPDF |
|---|---|
| InfoSheet | I4802InfoSheetPDF |
WangY,ZhaoY,LiuL,etal.Inhibitoryeffectsofimatinibmesylateonhumanepidermalmelanocytes.ClinExpDermatol.2014Mar;39(2):202-8.PMID:24479586.
D"allardD,GayJ,DescarpentriesC,etal.Tyrosinekinaseinhibitorsinducedown-regulationofc-KitbytargetingtheATPpocket.PLoSOne.2013Apr23;8(4):e60961.PMID:23637779.
Gambacorti-PasseriniCB,GunbyRH,PiazzaR,etal.MolecularmechanismsofresistancetoimatinibinPhiladelphia-chromosome-positiveleukaemias.LancetOncol.2003Feb;4(2):75-85.PMID:12573349.
LKT Labs
LKT实验室是一家专注于小分子的合成、纯化和分离的生化供应公司，用于研究应用。它的产品系列展示了已知的生物活性，在广泛的研究领域，特别是癌症和神经科学中得到了广泛的应用。这些产品包括蛋白激酶抑制剂、离子通道调节剂和激活剂。
LKT Laboratories is a biochemical supply company focused on the synthesis, purification, and isolation of small molecules for research applications. Its range of products exhibit known biological activities that have found uses in a wide array of research fields, especially cancer and neuroscience. These products include protein kinase inhibitors, ion channel modulators, and activators.
|
品牌 |
货号 |
名称 |
规格 |
|
LKT Labs |
444912-48-5 |
(2-iodo-5-nitrophenyl)-[1-[(1-methylpiperidin-2-yl)methyl]indol-3-yl]methanone |
1mg 5mg 25mg |
|
LKT Labs |
294646-77-8 |
(R)-CR8 |
1mg 5mg |
|
LKT Labs |
2377-31-3 |
(Z)-1,-BIS(2-METHOXY-5-(TRIFLUOROMETHYL)PHENYL)DIAZENE OXIDE |
1mg 5mg 25mg |
