Idarubicinisananthracyclineanddaunorubicinanalogthatexhibitsanticancerchemotherapeuticactivity;itisclinicallyusedtotreatleukemias.IdarubicinintercalatesDNA,inhibitingtopoisomeraseIIandinducingdouble-strandedDNAbreaksandcausinghistoneeviction.
| CasNo. | 57852-57-0 |
|---|---|
| Purity | ≥98% |
| Formula | C26H27NO9•HCl |
| FormulaWt. | 533.96 |
| ChemicalName | (7S,9S)-9-Acetyl-7-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,9,11-trihydroxy-5,12-naphthacenedionehydrochloride |
| IUPACName | (7S,9S)-9-acetyl-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-8,10-dihydro-7H-tetracene-5,12-dione;hydrochloride |
| Synonym | Idamycin;Zavedos |
| MeltingPoint | 183-185°C |
| Solubility | Solubleinwaterandmethanol. |
| Appearance | Orange-redpowder;odorless |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | I1400InfoSheetPDF |
|---|
EdaSatanaKaraH.Redoxmechanismofanticancerdrugidarubicinandin-situevaluationofinteractionwithDNAusinganelectRochemicalbiosensor.Bioelectrochemistry.2014Oct;99:17-23.PMID:24967755.
PangB,QiaoX,JanssenL,etal.Drug-inducedhistoneevictionfromopenchromatincontributestothechemotherapeuticeffectsofdoxorubicin.NatCommun.2013;4:1908.PMID:23715267.
CrivellariD,LombardiD,SpazzapanS,etal.Neworaldrugsinolderpatients:areviewofidarubicininelderlypatients.CritRevOncolHematol.2004Feb;49(2):153-63.PMID:15012975.
LKT Labs
LKT实验室是一家专注于小分子的合成、纯化和分离的生化供应公司，用于研究应用。它的产品系列展示了已知的生物活性，在广泛的研究领域，特别是癌症和神经科学中得到了广泛的应用。这些产品包括蛋白激酶抑制剂、离子通道调节剂和激活剂。
LKT Laboratories is a biochemical supply company focused on the synthesis, purification, and isolation of small molecules for research applications. Its range of products exhibit known biological activities that have found uses in a wide array of research fields, especially cancer and neuroscience. These products include protein kinase inhibitors, ion channel modulators, and activators.
|
品牌 |
货号 |
名称 |
规格 |
|
LKT Labs |
444912-48-5 |
(2-iodo-5-nitrophenyl)-[1-[(1-methylpiperidin-2-yl)methyl]indol-3-yl]methanone |
1mg 5mg 25mg |
|
LKT Labs |
294646-77-8 |
(R)-CR8 |
1mg 5mg |
|
LKT Labs |
2377-31-3 |
(Z)-1,-BIS(2-METHOXY-5-(TRIFLUOROMETHYL)PHENYL)DIAZENE OXIDE |
1mg 5mg 25mg |
