PF-04217903isatriazolopyrazineinhibitorofc-METthatdisplaysanticancerchemotherapeuticandanti-metastaticactivities.PF-04217903inhibitscellproliferation,invasion,andmigrationaswellastumorgrowthinvariouscancermodels.Inanimalmodelsofpancreaticneuroendocrinetumors,thiscompoundpreventslymphnodemetastasis.
| CasNo. | 1159490-85-3 |
|---|---|
| Purity | ≥98% |
| Formula | C19H16N8O |
| FormulaWt. | 372.38 |
| IUPACName | 2-{4-[1-(6-Quinolinylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl]-1H-pyrazol-1-yl}ethanol |
| Synonym | PF04217903 |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | P2012InfoSheetPDF |
|---|
SenninoB,Ishiguro-OonumaT,SchriverBJ,etal.Inhibitionofc-MetreduceslymphaticmetastasisinRIP-Tag2transgenicmice.CancerRes.2013Jun15;73(12):3692-703.PMID:23576559.
ZouHY,LiQ,LeeJH,etal.SensitivityofselectedhumantumormodelstoPF-04217903,anovelselectivec-Metkinaseinhibitor.MolCancerTher.2012Apr;11(4):1036-47.PMID:22389468.
TimofeevskiSL,McTigueMA,RyanK,etal.Enzymaticcharacterizationofc-Metreceptortyrosinekinaseoncogenicmutantsandkineticstudieswithaminopyridineandtriazolopyrazineinhibitors.Biochemistry.2009Jun16;48(23):5339-49.PMID:19459657.
LKT Labs
LKT实验室是一家专注于小分子的合成、纯化和分离的生化供应公司，用于研究应用。它的产品系列展示了已知的生物活性，在广泛的研究领域，特别是癌症和神经科学中得到了广泛的应用。这些产品包括蛋白激酶抑制剂、离子通道调节剂和激活剂。
LKT Laboratories is a biochemical supply company focused on the synthesis, purification, and isolation of small molecules for research applications. Its range of products exhibit known biological activities that have found uses in a wide array of research fields, especially cancer and neuroscience. These products include protein kinase inhibitors, ion channel modulators, and activators.
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品牌 |
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名称 |
规格 |
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LKT Labs |
444912-48-5 |
(2-iodo-5-nitrophenyl)-[1-[(1-methylpiperidin-2-yl)methyl]indol-3-yl]methanone |
1mg 5mg 25mg |
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LKT Labs |
294646-77-8 |
(R)-CR8 |
1mg 5mg |
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LKT Labs |
2377-31-3 |
(Z)-1,-BIS(2-METHOXY-5-(TRIFLUOROMETHYL)PHENYL)DIAZENE OXIDE |
1mg 5mg 25mg |
