PF-03758309isanATP-competitiveinhibitorofp21-activatedkinase4(PAK4),akinasetypicallyupregulatedinmanycancers.Thiscompoundexhibitsanticancerchemotherapeuticandanti-metastaticactivities.InhibitionofPAK4inhibitscellmotility,proliferation,andsurvivalincellularmodelsofcancerandsuppressestumorgrowthinanimalmodelsofcancer.PF-03758309alsoinhibitsfusionandmigrationofpreosteoclasts,osteoclastdifferentiation,andpodosomeformationincellularmodelsofosteoclast-relateddisorders.
| CasNo. | 1279034-84-2 |
|---|---|
| Purity | ≥99%,≥99%ee |
| Formula | C25H30N8OS•2HCl |
| FormulaWt. | 563.55 |
| Synonym | PF-3758309 |
| Solubility | SolubleinDMSO,waterandalcohols. |
| Appearance | Offwhitetopaleyellowpowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | P2000InfoSheetPDF |
|---|
ChoiSW,YeonJT,RyuBJ,etal.RepositioningPotentialofPAK4toOsteoclasticBoneResorption.JBoneMinerRes.2015Jan31.[Epubaheadofprint].PMID:25640698.
RyuBJ,LeeH,KimSH,etal.PF-3758309,p21-activatedkinase4inhibitor,suppressesmigrationandinvasionofA549humanlungcancercellsviaregulationofCREB,NF-κB,andβ-cateninsignalingsMolCellBiochem.2014Apr;389(1-2):69-77.PMID:24366569.
MurrayBW,GuoC,PirainoJ,etal.Small-moleculep21-activatedkinaseinhibitorPF-3758309isapotentinhibitorofoncogenicsignalingandtumorgrowth.ProcNatlAcadSciUSA.2010May18;107(20):9446-51.PMID:20439741.
www.clinicaltrials.gov/show/NCT00932126
LKT Labs
LKT实验室是一家专注于小分子的合成、纯化和分离的生化供应公司，用于研究应用。它的产品系列展示了已知的生物活性，在广泛的研究领域，特别是癌症和神经科学中得到了广泛的应用。这些产品包括蛋白激酶抑制剂、离子通道调节剂和激活剂。
LKT Laboratories is a biochemical supply company focused on the synthesis, purification, and isolation of small molecules for research applications. Its range of products exhibit known biological activities that have found uses in a wide array of research fields, especially cancer and neuroscience. These products include protein kinase inhibitors, ion channel modulators, and activators.
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规格 |
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LKT Labs |
444912-48-5 |
(2-iodo-5-nitrophenyl)-[1-[(1-methylpiperidin-2-yl)methyl]indol-3-yl]methanone |
1mg 5mg 25mg |
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294646-77-8 |
(R)-CR8 |
1mg 5mg |
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LKT Labs |
2377-31-3 |
(Z)-1,-BIS(2-METHOXY-5-(TRIFLUOROMETHYL)PHENYL)DIAZENE OXIDE |
1mg 5mg 25mg |
