Guanylin is a gastrointestinal peptide hormone that activates guanyl cyclase C primarily in intestinal epithelial cells, but also in neurons. Guanylin increases intracellular levels of cGMP and induces natriuresis and diuresis in the kidney. Guanylin inhibits cell proliferation of colonic cells, inducing cell cycle arrest.
| Cas No. | 145257-03-0 |
|---|---|
| Purity | ≥95% |
| Formula | C60H90N16O22S4 |
| Formula Wt. | 1515.74 |
| Appearance | White to off white powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | G8104 Info Sheet PDF |
|---|
Basu N, Saha S, Khan I, et al. Intestinal cell proliferation and senescence are regulated by receptor guanylyl cyclase C and p21. J Biol Chem. 2014 Jan 3;289(1):581-93. PMID: 24217248.
Fonteles MC, do Nascimento NR. Guanylin peptide family: history, interactions with ANP, and new pharmacological perspectives. Can J Physiol Pharmacol. 2011 Aug;89(8):575-85. PMID: 21815750.
Forte LR, Freeman RH, Krause WJ, et al. Guanylin peptides: cyclic GMP signaling mechanisms. Braz J Med Biol Res. 1999 Nov;32(11):1329-36. PMID: 10559833.
LKT Labs
LKT实验室是一家专注于小分子的合成、纯化和分离的生化供应公司，用于研究应用。它的产品系列展示了已知的生物活性，在广泛的研究领域，特别是癌症和神经科学中得到了广泛的应用。这些产品包括蛋白激酶抑制剂、离子通道调节剂和激活剂。
LKT Laboratories is a biochemical supply company focused on the synthesis, purification, and isolation of small molecules for research applications. Its range of products exhibit known biological activities that have found uses in a wide array of research fields, especially cancer and neuroscience. These products include protein kinase inhibitors, ion channel modulators, and activators.
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品牌 |
货号 |
名称 |
规格 |
|
LKT Labs |
444912-48-5 |
(2-iodo-5-nitrophenyl)-[1-[(1-methylpiperidin-2-yl)methyl]indol-3-yl]methanone |
1mg 5mg 25mg |
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LKT Labs |
294646-77-8 |
(R)-CR8 |
1mg 5mg |
|
LKT Labs |
2377-31-3 |
(Z)-1,-BIS(2-METHOXY-5-(TRIFLUOROMETHYL)PHENYL)DIAZENE OXIDE |
1mg 5mg 25mg |
