Description
MatrineisanalkaloidfoundinSophorathatexhibitsanticancerchemotherapeutic,antinociceptive,anti-inflammatory,neuroprotective,anti-fibrotic,andantiepileptic/anticonvulsantactivities.MatrineincreaseslevelsofBaxanddecreaseslevelsofBcl-2andVEGF-Ainnon-smallcelllungcancer(NSCLC)andhepatomacells,inducingapoptosisandinhibitingcellgrowth.Matrinealsoinhibitsgrowthofhepatocellularcarcinomatumorsinanimalmodels.Inanimalmodelsofchemicalandthermalpain(writhingandtailflicktests),matrinedecreasespainresponseinaκ-opioidreceptor(κOR)-andμ-opioidreceptor(μOR)-dependentmanner.Additionally,matrinedownregulateslevelsofglutamateandupregulateslevelsofGABA,regulatingglutamatesignalingandinhibitinginflammationanddemyelinationinanimalmodelsofexperimentalautoimmuneencephalitis(EAE)anddecreasingseizuresinseparateanimalmodels.MatrinealsoinhibitsJAK/STATsignaling,decreasingpulmonaryfibrosisinvivo.
References
KanQC,ZhangS,XuYM,etal.Matrineregulatesglutamate-relatedexcitotoxicfactorsinexperimentalautoimmuneencephalomyelitis.NeurosciLett.2014Feb7;560:92-7.PMID:24368216.
XiangJ,JiangY.Antiepilepticpotentialofmatrineviaregulationthelevelsofgamma-aminobutyricacidandglutamicacidinthebrain.IntJMolSci.2013Dec5;14(12):23751-61.PMID:24317434.
MaX,ChenR,LiuX,etal.EffectsofmatrineonJAK-STATsignalingtransductionpathwaysinbleomycin-inducedpulmonaryfibrosis.AfrJTrADItComplementAlternMed.2013Apr12;10(3):442-8.PMID:24146473.
ZhangY,ZhangH,YuP,etal.Effectsofmatrineagainstthegrowthofhumanlungcancerandhepatomacellsaswellaslungcancercellmigration.Cytotechnology.2009Apr;59(3):191-200.PMID:19649719.
MaL,WenS,ZhanY,etal.AnticancereffectsoftheChinesemedicinematrineonmurinehepatocellularcarcinomacells.PlantaMed.2008Feb;74(3):245-51.PMID:18283616.
XiaoP,KuboH,OhsawaM,etal.kappa-Opioidreceptor-mediatedantinociceptiveeffectsofstereoisomersandderivativesof(+)-matrineinmice.PlantaMed.1999Apr;65(3):230-3.PMID:10232067.