LeptomycinisapolyketideantibioticinitiallyproducedbyStreptomyces.Leptomycinexhibitsanticancerandantifungalactivity.LeptomycininhibitsCRM1,preventingnuclearexportofproteins.Inlungcancercells,leptomycininducesG1phasecellcyclearrest;incervicalcarcinomacells,leptomycinincreasesactivationofp53,inducingapoptosis.
| CasNo. | 87081-35-4 |
|---|---|
| Purity | ≥98% |
| Formula | C33H48O6 |
| FormulaWt. | 540.74 |
| ChemicalName | 19-(3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-8-oxo-2,10,12,16,18-Nonadecapentaenoicacid |
| IUPACName | (2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-19-[(2R,3S)-3-methyl-6-oxo-2,3-dihydropyran-2-yl]-8-oxononadeca-2,10,12,16,18-pentaenoicacid |
| Synonym | LMB;Elactocin,CI-940,CL-1957A,NSC-364372,PD-114720. |
| MeltingPoint | 41-44°C |
| Solubility | Solubleinethanolormethanol. |
| Appearance | ClearcolorlesssolutioninabsoluteETOH |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | L1761MSDSPDF |
|---|---|
| InfoSheet | L1761InfoSheetPDF |
SunQ,CarrascoYP,HuY,etal.NuclearexportinhibitionthroughcovalentconjugationandhydrolysisofLeptomycinBbyCRM1.ProcNatlAcadSciUSA.2013Jan22;110(4):1303-8.PMID:23297231.
AbkalloHM,KawanoH,WatanabeK,etal.Anewcell-basedreportersystemforsensitivescreeningofnuclearexportinhibitors.DrugDiscovTher.2011Dec;5(6):286-92.PMID:22466439.
LuC,ShaoC,CobosE,etal.ChemotherapeuticsensitizationofleptomycinBresistantlungcancercellsbypretreatmentwithdoxorubicin.PLoSOne.2012;7(3):e32895.PMID:22412944.
HamamotoT,GunjiS,TsujiH,etal.LeptomycinsAandB,newantifungalantibiotics.I.Taxonomyoftheproducingstrainandtheirfermentation,purificationandcharacterization.JAntibiot(Tokyo).1983Jun;36(6):639-45.PMID:6874585.
LKT Labs
LKT实验室是一家专注于小分子的合成、纯化和分离的生化供应公司，用于研究应用。它的产品系列展示了已知的生物活性，在广泛的研究领域，特别是癌症和神经科学中得到了广泛的应用。这些产品包括蛋白激酶抑制剂、离子通道调节剂和激活剂。
LKT Laboratories is a biochemical supply company focused on the synthesis, purification, and isolation of small molecules for research applications. Its range of products exhibit known biological activities that have found uses in a wide array of research fields, especially cancer and neuroscience. These products include protein kinase inhibitors, ion channel modulators, and activators.
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品牌 |
货号 |
名称 |
规格 |
|
LKT Labs |
444912-48-5 |
(2-iodo-5-nitrophenyl)-[1-[(1-methylpiperidin-2-yl)methyl]indol-3-yl]methanone |
1mg 5mg 25mg |
|
LKT Labs |
294646-77-8 |
(R)-CR8 |
1mg 5mg |
|
LKT Labs |
2377-31-3 |
(Z)-1,-BIS(2-METHOXY-5-(TRIFLUOROMETHYL)PHENYL)DIAZENE OXIDE |
1mg 5mg 25mg |
