LKT/CLODRONATE DISODIUM TETRAHYDRATE/C3449/100 mg,LKT Labs,,LKT Labs,lktlabs,+,,Array.Array.Array蚂蚁淘厂家直采.

ProductIDC3449

CasNo.88416-50-6

Purity≥98%

Description
ProductInfo
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References

Description

Clodronateisafirst-generationnon-nitrogen-containingbisphosphonatethatisusedclinicallyforitsanti-resorptiveactivity.Clodronategeneratesformationofanon-hydrolysableβ-γATPanalogthatinhibitsmitochondrialADP/ATPtranslocaseandpreventsmitochondrialoxygenconsumptionandfunction;asaresult,osteoblastcalciumdepositionisinhibitedandapoptosisisinducedinosteoclasts,inhibitingboneresorption.ClodronatealsodecreasesexpressionofMMP9andimprovesperformanceontheRotarodtest,decreasingseverityofexperimentalautoimmuneneuritis,ananimalmodelofGuillan-BarreSyndrome.Additionally,clodronateexhibitsanticancerchemotherapeuticandanti-angiogenicactivities,decreasingvesseldensityinvivoandinhibitingcellularproliferationinmodelsofrenalcellcarcinoma.

ProductInfo

CasNo.	88416-50-6
Purity	≥98%
Formula	CH₂Cl₂Na₂O₆P₂•4H₂O
FormulaWt.	360.92
ChemicalName	Clodronatedisodiumsalt;Dichloromethylene-bisphophonatedisodiumtetrahydrate
IUPACName	disodium;[dichloro-[hydroxy(oxido)phosphoryl]methyl]-hydroxyphosphinate
Synonym	Clodronicaciddisodiumsalt,chlodronatesodium,clasteron
Solubility	Solubleinwaterto100mM
Appearance	WhiteCrystalPowder

ShippingandStorage

StoreTemp	Ambient
ShipTemp	Ambient

Downloads

MSDS	C3449MSDSPDF
InfoSheet	C3449InfoSheetPDF

References

KatzavA,BinaH,AronovichR,etal.Treatmentforexperimentalautoimmuneneuritiswithclodronate(Bonefos).ImmunolRes.2013Jul;56(2-3):334-40.PMID:23579773.

SoltauJ,ZirrgiebelU,EsserN,etal.AntitumoralandantiangiogenicefficacyofbisphosphonatesinvitroandinamurineRENCAmodel.AnticancerRes.2008Mar-Apr;28(2A):933-41.PMID:18507039.

KellinsalmiM,MönkkönenH,MönkkönenJ,etal.Invitrocomparisonofclodronate,pamidronateandzoledronicacideffectsonratosteoclastsandhumanstemcell-derivedosteoblasts.BasicClinPharmacolToxicol.2005Dec;97(6):382-91.PMID:16364054.

ReszkaAA,RodanGA.Mechanismofactionofbisphosphonates.CurrOsteoporosRep.2003Sep;1(2):45-52.PMID:16036064.

RogersMJ.Newinsightsintothemolecularmechanismsofactionofbisphosphonates.CurrPharmDes.2003;9(32):2643-58.PMID:14529538.

LehenkariPP,KellinsalmiM,NäpänkangasJP,etal.Furtherinsightintomechanismofactionofclodronate:inhibitionofmitochondrialADP/ATPtranslocasebyanonhydrolyzable,adenine-containingmetabolite.MolPharmacol.2002May;61(5):1255-62.PMID:11961144.

SatoA,NakashimaH,NakashimaM,etal.InvolvementoftheTNFandFasLproducedbyCD11bKupffercells/macrophagesinCCl4-inducedacutehepaticinjury.PLoSOne.2014Mar25;9(3):e92515.PMID:24667392.

KimuraK,NakamuraY,InabaY,etal.Histidineaugmentsthesuppressionofhepaticglucoseproductionbycentralinsulinaction.Diabetes.2013Jul;62(7):2266-2277.PMID:23474485.

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