Resiniferonol-9,13,14-orthophenylacetate(ROPA)isaditerpenevanilloidderivativeofresiniferatoxin.Invitro,ROPAinducesG1/Sphasecellcyclearrest,downregulatesexpressionofcyclinD1,upregulatesexpressionofp21,andinducesactivationofERK1/2,JNK1/2,andMAPKs.ROPAmayactivatePKC,promotingcarcinogenesisandactingasatumorpromoter.
| CasNo. | 57852-42-3 |
|---|---|
| Purity | ≥98% |
| Formula | C28H32O6 |
| FormulaWt. | 464.56 |
| ChemicalName | Daphnetoxin,6,7-deepoxy-6,7-didehydro-5-deoxy-21-dephenyl-21-(phenylmethyl)- |
| Synonym | ROPA;ROP |
| Solubility | SolubleinDMSOorethanol. |
| Appearance | WhiteCrystalPowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | R1775InfoSheetPDF |
|---|
FreyMR,ClarkJA,BatemanNW,etal.Cellcycle-andproteinkinaseC-specificeffectsofresiniferatoxinandresiniferonol9,13,14-ortho-phenylacetateinintestinalepithelialcells.BiochemPharmacol.2004May15;67(10):1873-86.PMID:15130764.
GeigesD,MeyerT,MarteB,etal.ActivationofproteinkinaseCsubtypesalpha,gamma,delta,epsilon,zeta,andetabytumor-promotingandnontumor-promotingagents.BiochemPharmacol.1997Mar21;53(6):865-75.PMID:9113106.
LKT Labs
LKT实验室是一家专注于小分子的合成、纯化和分离的生化供应公司，用于研究应用。它的产品系列展示了已知的生物活性，在广泛的研究领域，特别是癌症和神经科学中得到了广泛的应用。这些产品包括蛋白激酶抑制剂、离子通道调节剂和激活剂。
LKT Laboratories is a biochemical supply company focused on the synthesis, purification, and isolation of small molecules for research applications. Its range of products exhibit known biological activities that have found uses in a wide array of research fields, especially cancer and neuroscience. These products include protein kinase inhibitors, ion channel modulators, and activators.
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LKT Labs |
444912-48-5 |
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1mg 5mg 25mg |
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294646-77-8 |
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1mg 5mg |
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LKT Labs |
2377-31-3 |
(Z)-1,-BIS(2-METHOXY-5-(TRIFLUOROMETHYL)PHENYL)DIAZENE OXIDE |
1mg 5mg 25mg |
