Enniatinsareagroupofmycotoxinsproducedbyseveralfungalspecies.Theyarecyclichexadepsipeptidesstructurallyrelatedtobeauvericin.Theymaybefoundascontaminantsinfoodcommodities,particularlyincerealgrains.EnniatinsarefoundtohaveavarietyofBIOLOGicalactivitiesincludinginsecticidal,antifungal,antibioticandcytotoxicproperties.Theyhavebeenshowntoinduceapoptosisinseveralhumancancercelllinesandaregaininginterestaspotentialanticancerdrugs.
| CasNo. | 2503-13-1 |
|---|---|
| Purity | ≥97% |
| Formula | C36H63N3O9 |
| FormulaWt. | 681.91 |
| ChemicalName | (3S,9S,12R,15S,18R)-9,15-bis[(2S)-butan-2-yl]-3-[(2R)-butan-2-yl]-4,10,16-trimethyl-6,12,18-tri(propan-2-yl)-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone |
| IUPACName | (3S,6R,9S,12R,15S,18R)-3,9,15-Tri[(2S)-2-butanyl]-6,12,18-triisopropyl-4,10,16-trimethyl-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone |
| Synonym | Fusafungine,cyclo[N(Me)Ile-D-OVal-N(Me)Ile-DL-OVal-N(Me)aIle-D-OVal] |
| MeltingPoint | 121-125°C |
| Solubility | Solubleinethanol,methanol,DMSO,DMF.Insolubleinwater. |
| Appearance | Whitepowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | E537332InfoSheetPDF |
|---|
LiuzziVC,MirabelliV,CimmarustiMT,etal.EnniatinandbeauvericinbiosynthesisinFusariumspecies:productionprofilesandstructuraldeterminantprediction.Toxins(Basel).2017Feb;9(2):45.PMID:28125067.
GunterAB,HermansA,BosnichW,etal.ProteinengineeringofSaccharomycescerevisiaetransporterPdr5pidentifieskeyresiduesthatimpactFusariummycotoxinexportandresistancetoinhibition.Microbiologyopen.2016Dec;5(6):979-991.PMID:27263049.
NazariF,SulyokM,KobarfardF,etal.Evaluationofemergingmycotoxinsbeauvericin,enniatins,fusaproliferinandmoniliforminindomesticriceinIran.IranJPharmRes.2015Spring;14(2):505-512.PMID:25901158.
Dornetshuber-FleissR,HeilosD,MohrT,etal.ThenaturallybornfusariotoxinenniatinBandsorafenibexertsynergisticactivityagainstcervicalcancerinvitroandinvivo.BiochemPharmacol.2015Feb1;93(3):318-331.PMID:25557295.
LKT Labs
LKT实验室是一家专注于小分子的合成、纯化和分离的生化供应公司，用于研究应用。它的产品系列展示了已知的生物活性，在广泛的研究领域，特别是癌症和神经科学中得到了广泛的应用。这些产品包括蛋白激酶抑制剂、离子通道调节剂和激活剂。
LKT Laboratories is a biochemical supply company focused on the synthesis, purification, and isolation of small molecules for research applications. Its range of products exhibit known biological activities that have found uses in a wide array of research fields, especially cancer and neuroscience. These products include protein kinase inhibitors, ion channel modulators, and activators.
|
品牌 |
货号 |
名称 |
规格 |
|
LKT Labs |
444912-48-5 |
(2-iodo-5-nitrophenyl)-[1-[(1-methylpiperidin-2-yl)methyl]indol-3-yl]methanone |
1mg 5mg 25mg |
|
LKT Labs |
294646-77-8 |
(R)-CR8 |
1mg 5mg |
|
LKT Labs |
2377-31-3 |
(Z)-1,-BIS(2-METHOXY-5-(TRIFLUOROMETHYL)PHENYL)DIAZENE OXIDE |
1mg 5mg 25mg |
