Desmopressin is a synthetic peptide derivative of arginine vasopressin that binds and activates vasopressin-2 receptors (V2Rs). Desmopressin exhibits pro-coagulant/pro-thrombotic and antidiuretic activities and is clinically used to treat bleeding disorders such as hemophilia. Desmopressin enhances platelet pro-coagulant activity and increase platelet-dependent thrombin generation in a Na+/Ca2+-dependent manner.
| Cas No. | 16679-58-6 |
|---|---|
| Purity | ≥95% |
| Formula | C46H64N14O12S2 |
| Formula Wt. | 1069.24 |
| IUPAC Name | N-[1-[(2-amino-2-oxoethyl)amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-1-[7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamide |
| Appearance | White to off white powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | D1777 Info Sheet PDF |
|---|
Colucci G, Stutz M, Rochat S, et al. The effect of desmopressin on platelet function: a selective enhancement of procoagulant COAT-platelets in patients with primary platelet function defects. Blood. 2014 Jan 17. [Epub ahead of print]. PMID: 24443440.
Leissinger C, Carcao M, Gill JC, et al. Desmopressin (DDAVP) in the management of patients with congenital bleeding disorders. Haemophilia. 2014 Mar;20(2):158-67. PMID: 23937614.
Juul KV, Klein BM, Sandström R, et al. Gender difference in antidiuretic response to desmopressin. Am J Physiol Renal Physiol. 2011 May;300(5):F1116-22. PMID: 21367921.
Slusarz MJ, Slusarz R, Ciarkowski J. Investigation of mechanism of desmopressin binding in vasopressin V2 receptor versus vasopressin V1a and oxytocin receptors: molecular dynamics simulation of the agonist-bound state in the membrane-aqueous system. Biopolymers. 2006 Apr 5;81(5):321-38. PMID: 16333859.
LKT Labs
LKT实验室是一家专注于小分子的合成、纯化和分离的生化供应公司，用于研究应用。它的产品系列展示了已知的生物活性，在广泛的研究领域，特别是癌症和神经科学中得到了广泛的应用。这些产品包括蛋白激酶抑制剂、离子通道调节剂和激活剂。
LKT Laboratories is a biochemical supply company focused on the synthesis, purification, and isolation of small molecules for research applications. Its range of products exhibit known biological activities that have found uses in a wide array of research fields, especially cancer and neuroscience. These products include protein kinase inhibitors, ion channel modulators, and activators.
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品牌 |
货号 |
名称 |
规格 |
|
LKT Labs |
444912-48-5 |
(2-iodo-5-nitrophenyl)-[1-[(1-methylpiperidin-2-yl)methyl]indol-3-yl]methanone |
1mg 5mg 25mg |
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LKT Labs |
294646-77-8 |
(R)-CR8 |
1mg 5mg |
|
LKT Labs |
2377-31-3 |
(Z)-1,-BIS(2-METHOXY-5-(TRIFLUOROMETHYL)PHENYL)DIAZENE OXIDE |
1mg 5mg 25mg |
