CyclosporinAisacyclicpeptidethatexhibitsimmunosuppressiveactivity.CyclosporinAisclinicallyusedtopreventrejectioninorgantransplantsandtotreatorpreventgraft-versus-hostdisease(GvHD).CyclosporinAbindscyclophilin,inhibitingcalcineurinanddecreasinglevelsofIL-2andactivatedTcells.CyclosporinAalsoshowsbenefitinthetreatmentoftraumaticbraininjury.
| CasNo. | 59865-13-3 |
|---|---|
| Purity | ≥98% |
| Formula | C62H111N11O12 |
| FormulaWt. | 1202.61 |
| IUPACName | (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(E,1R,2R)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone |
| Synonym | Cyclosporine;Ciclosporin;Sandimmun;Neoral |
| MeltingPoint | 148-151°C |
| Solubility | Solubleinmethanol,ethanol,acetone,etherorchloroform.Veryslightlysolubleinwater. |
| Appearance | WhiteCrystalPowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | C9611MSDSPDF |
|---|---|
| InfoSheet | C9611InfoSheetPDF |
LulicD,BurnsJ,BaeEC,etal.AreviewoflaboratoryandclinicaldatasupportingthesafetyandefficacyofcyclosporinAintraumaticbraininjury.Neurosurgery.2011May;68(5):1172-86.PMID:21307793.
ReynoldsNJ,Al-DarajiWI.Calcineurininhibitorsandsirolimus:mechanismsofactionandapplicationsindermatology.ClinExpDermatol.2002Oct;27(7):555-61.PMID:12464150.
HandschumacherRE,HardingMW,RiceJ,etal.Cyclophilin:aspecificcytosolicbindingproteinforcyclosporinA.Science.1984Nov2;226(4674):544-7.PMID:6238408.
KosekiN,DeguchiJ,YamashitaA,etal.Establishmentfoanovelexperimentalprotocolfordrug-inducedseizureliABIlityscreeningbasedonalocomotoractivityassayinzebrafish.JToxicolSci.2014Aug;39(4):579-600.PMID:25056783.
LKT Labs
LKT实验室是一家专注于小分子的合成、纯化和分离的生化供应公司，用于研究应用。它的产品系列展示了已知的生物活性，在广泛的研究领域，特别是癌症和神经科学中得到了广泛的应用。这些产品包括蛋白激酶抑制剂、离子通道调节剂和激活剂。
LKT Laboratories is a biochemical supply company focused on the synthesis, purification, and isolation of small molecules for research applications. Its range of products exhibit known biological activities that have found uses in a wide array of research fields, especially cancer and neuroscience. These products include protein kinase inhibitors, ion channel modulators, and activators.
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品牌 |
货号 |
名称 |
规格 |
|
LKT Labs |
444912-48-5 |
(2-iodo-5-nitrophenyl)-[1-[(1-methylpiperidin-2-yl)methyl]indol-3-yl]methanone |
1mg 5mg 25mg |
|
LKT Labs |
294646-77-8 |
(R)-CR8 |
1mg 5mg |
|
LKT Labs |
2377-31-3 |
(Z)-1,-BIS(2-METHOXY-5-(TRIFLUOROMETHYL)PHENYL)DIAZENE OXIDE |
1mg 5mg 25mg |
