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主营:防癌抗癌特殊化学品试剂
℡ 4000-520-616
℡ 4000-520-616
LKT/RG-108/R2400/10 mg
产品编号:R2400-10mg
市  场 价:¥2300.00
场      地:美国(厂家直采)
产品分类: 其它>其它试剂>临床研究>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$115.00
品      牌: LKT Labs
公      司:LKT Laboratories, Inc
公司分类:
LKT/RG-108/R2400/10 mg
商品介绍
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References

Description

RG-108 is an inhibitor of DNA methyltransferases (DNMTs) that exhibits antidepressant, neuromodulatory, anticancer, and antiepileptic activities. RG-108 attenuates stress-induced behavioral adaptations in animal models and inhibits persistent epileptiform activity. RG-108 also increases TERT expression. In prostate cancer cells, this compound induces apoptosis and inhibits cell growth.

Product Info

Cas No.

48208-26-0

Purity

≥98%

Formula

C19H14N2O4

Formula Wt.

334.33

IUPAC Name

(2S)-2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

Info Sheet

R2400 Info Sheet PDF

References

Sales AJ, Joca SR. Effects of DNA methylation inhibitors and conventional antidepressants on mice behaviour and brain DNA methylation levels. Acta Neuropsychiatr. 2015 Jun 26:1-12. PMID: 26112212.

Oh YS, Jeong SG, Cho GW. Anti-senescence effects of DNA methyltransferase inhibitor RG108 in human bone marrow mesenchymal stromal cells. Biotechnol Appl Biochem. 2015 May 8. [Epub ahead of print]. PMID: 25952632.

Graça I, Sousa EJ, Baptista T, et al. Anti-tumoral effect of the non-nucleoside DNMT inhibitor RG108 in human prostate cancer cells. Curr Pharm Des. 2014;20(11):1803-11. PMID: 23888969.

Machnes ZM, Huang TC, Chang PK, et al. DNA methylation mediates persistent epileptiform activity in vitro and in vivo. PLoS One. 2013 Oct 2;8(10):e76299. PMID: 24098468.

品牌介绍

LKT Labs


LKT实验室是一家专注于小分子的合成、纯化和分离的生化供应公司,用于研究应用。它的产品系列展示了已知的生物活性,在广泛的研究领域,特别是癌症和神经科学中得到了广泛的应用。这些产品包括蛋白激酶抑制剂、离子通道调节剂和激活剂。


LKT Laboratories is a biochemical supply company focused on the synthesis, purification, and isolation of small molecules for research applications. Its range of products exhibit known biological activities that have found uses in a wide array of research fields, especially cancer and neuroscience. These products include protein kinase inhibitors, ion channel modulators, and activators.


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