Pramipexole is an agonist at D2/3 receptors that is clinically used to treat symptoms of Parkinson’s disease. Pramipexole exhibits neuroprotective and antidepressant activities. In animal models, pramipexole decreases immobility time in the forced swim test. In vitro, this compound inhibits LPS-induced degeneration of neurons and also inhibits phosphorylation of α-synuclein.
| Cas No. | 191217-81-9 |
|---|---|
| Purity | ≥98% |
| Formula | C10H17N3S • 2HCl • H2O |
| Formula Wt. | 302.26 |
| Chemical Name | (S)-2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydrochloride |
| IUPAC Name | (6S)-6-N-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine;hydrate;dihydrochloride |
| Melting Point | 288-290°C |
| Appearance | White to off white powder |
| Store Temp | Ambient |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | P6901 Info Sheet PDF |
|---|
Chau KY, Cooper JM, Schapira AH. Pramipexole reduces phosphorylation of α-synuclein at serine-129. J Mol Neurosci. 2013 Oct;51(2):573-80. PMID: 23681749.
Kitagawa K, Kitamura Y, Miyazaki T, et al. Effects of pramipexole on the duration of immobility during the forced swim test in normal and ACTH-treated rats. Naunyn Schmiedebergs Arch Pharmacol. 2009 Jul;380(1):59-66. PMID: 19274453.
Iravani MM, Sadeghian M, Leung CC, et al. Continuous subcutaneous infusion of pramipexole protects against lipopolysaccharide-induced dopaminergic cell death without affecting the inflammatory response. Exp Neurol. 2008 Aug;212(2):522-31. PMID: 18571649.
Zarate CA Jr, Payne JL, Singh J, et al. Pramipexole for bipolar II depression: a placebo-controlled proof of concept study. Biol Psychiatry. 2004 Jul 1;56(1):54-60. PMID: 15219473.
Ling ZD, Robie HC, Tong CW, et al. Both the antioxidant and D3 agonist actions of pramipexole mediate its neuroprotective actions in mesencephalic cultures. J Pharmacol Exp Ther. 1999 Apr;289(1):202-10. PMID: 10087005.
Ono K, Takasaki J, Takahashi R, et al. Effects of antiparkinsonian agents on beta-amyloid and alpha-synuclein oligomer formation in vitro. J Neurosci Res. 2013 Oct;91(10):1371-1381. PMID: 23913715.
LKT Labs
LKT实验室是一家专注于小分子的合成、纯化和分离的生化供应公司，用于研究应用。它的产品系列展示了已知的生物活性，在广泛的研究领域，特别是癌症和神经科学中得到了广泛的应用。这些产品包括蛋白激酶抑制剂、离子通道调节剂和激活剂。
LKT Laboratories is a biochemical supply company focused on the synthesis, purification, and isolation of small molecules for research applications. Its range of products exhibit known biological activities that have found uses in a wide array of research fields, especially cancer and neuroscience. These products include protein kinase inhibitors, ion channel modulators, and activators.
|
品牌 |
货号 |
名称 |
规格 |
|
LKT Labs |
444912-48-5 |
(2-iodo-5-nitrophenyl)-[1-[(1-methylpiperidin-2-yl)methyl]indol-3-yl]methanone |
1mg 5mg 25mg |
|
LKT Labs |
294646-77-8 |
(R)-CR8 |
1mg 5mg |
|
LKT Labs |
2377-31-3 |
(Z)-1,-BIS(2-METHOXY-5-(TRIFLUOROMETHYL)PHENYL)DIAZENE OXIDE |
1mg 5mg 25mg |
