DermenkephalinisanexogenousopioidpeptidethatactsasanagoNISTatδ-opioidreceptors(selectiveforδ-2receptors).Dermenkephalin,likeotherδORagonists,exhibitsantinociceptive/analgesicactivity,increasingresponselatencyinanimalmodelsofthermalpain.Dermenkephalinalsoplaysaroleinrewardandreinforcementsignaling,inducingconditionedplacepreferenceinanimalmodelspreviouslyadministeredethanolorcocaine.Dermenkephalinalsoincreaseslocomotoractivityinanimalmodels.
| CasNo. | 119975-64-3 |
|---|---|
| Purity | ≥95% |
| Formula | C44H62N10O10S2 |
| FormulaWt. | 955.17 |
| IUPACName | (3S)-4-amino-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylsulfanylbutanoyl]amino]-3-phenylpropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]-4-methylsulfanylbutanoyl]amino]-4-oxobutanoicacid |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | D1767MSDSPDF |
|---|---|
| InfoSheet | D1767InfoSheetPDF |
MitchellJM,MargolisEB,CokerAR,etal.Intra-VTAdeltorphin,butnotDPDPE,inducesplacepreferenceinethanol-drinkingrats:distinctDOR-1andDOR-2mechanismscontrolethanolconsumptionandreward.AlcoholClinExpRes.2014Jan;38(1):195-203.PMID:24033469.
FraserGL,ParenteauH,TuTM,etal.TheeffectsofdeltaagonistsonlocomotoractivityinhABItuatedandnon-habituatedrats.LifeSci.2000Jul14;67(8):913-22.PMID:10946851.
HarasawaI,FieldsHL,MengID.Deltaopioidreceptormediatedactionsintherostralventromedialmedullaontailflicklatencyandnociceptivemodulatoryneurons.Pain.2000Mar;85(1-2):255-62.PMID:10692626.
LKT Labs
LKT实验室是一家专注于小分子的合成、纯化和分离的生化供应公司，用于研究应用。它的产品系列展示了已知的生物活性，在广泛的研究领域，特别是癌症和神经科学中得到了广泛的应用。这些产品包括蛋白激酶抑制剂、离子通道调节剂和激活剂。
LKT Laboratories is a biochemical supply company focused on the synthesis, purification, and isolation of small molecules for research applications. Its range of products exhibit known biological activities that have found uses in a wide array of research fields, especially cancer and neuroscience. These products include protein kinase inhibitors, ion channel modulators, and activators.
|
品牌 |
货号 |
名称 |
规格 |
|
LKT Labs |
444912-48-5 |
(2-iodo-5-nitrophenyl)-[1-[(1-methylpiperidin-2-yl)methyl]indol-3-yl]methanone |
1mg 5mg 25mg |
|
LKT Labs |
294646-77-8 |
(R)-CR8 |
1mg 5mg |
|
LKT Labs |
2377-31-3 |
(Z)-1,-BIS(2-METHOXY-5-(TRIFLUOROMETHYL)PHENYL)DIAZENE OXIDE |
1mg 5mg 25mg |
