DAMGOisasyntheticpeptideμ-opioidreceptoragoNIST(μOR)thatexhibitsneuromodulatoryandantinociceptive/analgesicactivities.DAMGOdecreasespaineffectsinanimalmodelsofvisceralpainandalsodecreasesmotoractivityinseparateanimalmodels.Invitroandinvivo,DAMGOdecreaseslevelsoftheglutamatetransporterEAAT3anddecreasesGABA-Acurrent.
| Purity | ≥95% |
|---|---|
| Formula | C26H35N5O6 |
| FormulaWt. | 513.0 |
| IUPACName | (2S)-2-amino-N-[(2R)-1-[[2-[[(2S)-1-(2-hydroxyethylamino)-1-oxo-3-phenylpropan-2-yl]-methylamino]-2-oxoethyl]amino]-1-oxopropan-2-yl]-3-(4-hydroxyphenyl)propanamide |
| Synonym | DAGO;DAMGE |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | D0025InfoSheetPDF |
|---|
WuQ,XiaS,LinJ,etal.Effectsofthealteredactivityofδ-opioidreceptorontheexpressionofglutamatetransportertype3inducedbychronicexposuretomorphine.JNeurolSci.2013Dec15;335(1-2):174-81.PMID:24120272.
AlexeevaEV,NazarovaGA,SudakovSK.Effectsofperipheralμ,δ,andΚ-opioidreceptoragonistsonthelevelsofanxietyandmotoractivityofrats.BullExpBiolMed.2012Sep;153(5):720-1.PMID:23113268.
HermanMA,GillisRA,ViciniS,etal.TonicGABAAreceptorconductanceinmedialsubnucleusofthetractussolitariusneuronsisinhibitedbyactivationofμ-opioidreceptors.JNeurophysiol.2012Feb;107(3):1022-31.PMID:22114164.
Al-KhrasaniM,LackóE,RibaP,etal.Thecentralversusperipheralantinociceptiveeffectsofμ-opioidreceptoragonistsinthenewmodelofratvisceralpain.BrainResBull.2012Feb10;87(2-3):238-43.PMID:22079588.
LKT Labs
LKT实验室是一家专注于小分子的合成、纯化和分离的生化供应公司，用于研究应用。它的产品系列展示了已知的生物活性，在广泛的研究领域，特别是癌症和神经科学中得到了广泛的应用。这些产品包括蛋白激酶抑制剂、离子通道调节剂和激活剂。
LKT Laboratories is a biochemical supply company focused on the synthesis, purification, and isolation of small molecules for research applications. Its range of products exhibit known biological activities that have found uses in a wide array of research fields, especially cancer and neuroscience. These products include protein kinase inhibitors, ion channel modulators, and activators.
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品牌 |
货号 |
名称 |
规格 |
|
LKT Labs |
444912-48-5 |
(2-iodo-5-nitrophenyl)-[1-[(1-methylpiperidin-2-yl)methyl]indol-3-yl]methanone |
1mg 5mg 25mg |
|
LKT Labs |
294646-77-8 |
(R)-CR8 |
1mg 5mg |
|
LKT Labs |
2377-31-3 |
(Z)-1,-BIS(2-METHOXY-5-(TRIFLUOROMETHYL)PHENYL)DIAZENE OXIDE |
1mg 5mg 25mg |
