PhytanicacidisafattyacidmetaboliteofchlorophyllthatactsasaligandofretinoidXreceptors(RXRs)andperoxisomeproliferator-activatedreceptors(PPARs)andisknowntoregulateglucosemetabolism.PhytanicacidalsoplaysaroleindisordersofperoxisomalmetabolismsuchasRefsumdisease.Thiscompoundinducesapoptosisbyuncouplingoxidativephosphorylation,stimulatingROSgeneration,andactivatingthefreefattyacidreceptorGPR40toalterintracellularCa2+levels.
| CasNo. | 14721-66-5 |
|---|---|
| Purity | ≥97% |
| Formula | C20H40O2 |
| FormulaWt. | 312.53 |
| IUPACName | 3,7,11,15-tetramethylhexadecanoicacid |
| Synonym | 3,7,11,15-Tetramethylhexadecanoicacid |
| Appearance | Liquid |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | P3198InfoSheetPDF |
|---|
CheBN,OksbjergN,HellgrenLI,etal.Phytanicacidstimulatesglucoseuptakeinamodelofskeletalmuscles,theprimaryporcinemyotubes.LipidsHealthDis.2013Feb11;12:14.PMID:23398851.
BusanelloEN,AmaralAU,ToninAM,etal.Disruptionofmitochondrialhomeostasisbyphytanicacidincerebellumofyoungrats.Cerebellum.2013Jun;12(3):362-9.PMID:23081695.
KruskaN,ReiserG.Phytanicacidandpristanicacid,branched-chainfattyacidsassociatedwithRefsumdiseaseandotherinheritedperoxisomaldisorders,mediateintracellularCa2+signalingthroughactivationoffreefattyacidreceptorGPR40.NeurobiolDis.2011Aug;43(2):465-72.PMID:21570468.
SchönfeldP,KahlertS,ReiserG.Astudyofthecytotoxicityofbranched-chainphytanicacidwithmitochondriaandratbrainastrocytes.ExpGerontol.2006Jul;41(7):688-96.PMID:16616447.
LKT Labs
LKT实验室是一家专注于小分子的合成、纯化和分离的生化供应公司，用于研究应用。它的产品系列展示了已知的生物活性，在广泛的研究领域，特别是癌症和神经科学中得到了广泛的应用。这些产品包括蛋白激酶抑制剂、离子通道调节剂和激活剂。
LKT Laboratories is a biochemical supply company focused on the synthesis, purification, and isolation of small molecules for research applications. Its range of products exhibit known biological activities that have found uses in a wide array of research fields, especially cancer and neuroscience. These products include protein kinase inhibitors, ion channel modulators, and activators.
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LKT Labs |
444912-48-5 |
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294646-77-8 |
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1mg 5mg |
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2377-31-3 |
(Z)-1,-BIS(2-METHOXY-5-(TRIFLUOROMETHYL)PHENYL)DIAZENE OXIDE |
1mg 5mg 25mg |
