Penitrem A is a neuroactive mycotoxin initially produced by species of Penicillum. Penitrem A exhibits tremorgenic activity. In vitro and in vivo, penitrem A inhibits Ca2+/voltage-sensitive K+ (BK) channels. Penitrem A also potentiates GABA-A receptor function in the forebrain and inhibits uptake of GABA and glutamate into synaptosomes. Additionally, penitrem A may disrupt learning acquisition but not memory or task performance in animal models examining passive avoidance testing.
| Cas No. | 12627-35-9 |
|---|---|
| Purity | ≥98% |
| Formula | C37H44ClNO6 |
| Formula Wt. | 634.20 |
| Synonym | Tremortin A |
| Melting Point | 224-230°C(dec) |
| Solubility | Acetone, Methanol, and DMSO. |
| Appearance | White Powder |
| Store Temp | 4°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | P1952 Info Sheet PDF |
|---|
Moldes-Anaya A, Rundberget T, Fæste CK, et al. Neurotoxicity of Penicillium crustosum secondary metabolites: tremorgenic activity of orally administered penitrem A and thomitrem A and E in mice. Toxicon. 2012 Dec 15;60(8):1428-35. PMID: 23085423.
Asano S, Bratz IN, Berwick ZC, et al. Penitrem A as a tool for understanding the role of large conductance Ca(2+)/voltage-sensitive K(+) channels in vascular function. J Pharmacol Exp Ther. 2012 Aug;342(2):453-60. PMID: 22580348.
Moldes-Anaya AS, Fonnum F, Eriksen GS, et al. In vitro neuropharmacological evaluation of penitrem-induced tremorgenic syndromes: importance of the GABAergic system. Neurochem Int. 2011 Dec;59(7):1074-81. PMID: 21924313.
Deschaux O, Bizot JC. Effects of penitrem A on rat's performances in passive avoidance and Morris water maze tests. Mycopathologia. 1997;138(2):99-104. PMID: 9433810.
LKT Labs
LKT实验室是一家专注于小分子的合成、纯化和分离的生化供应公司，用于研究应用。它的产品系列展示了已知的生物活性，在广泛的研究领域，特别是癌症和神经科学中得到了广泛的应用。这些产品包括蛋白激酶抑制剂、离子通道调节剂和激活剂。
LKT Laboratories is a biochemical supply company focused on the synthesis, purification, and isolation of small molecules for research applications. Its range of products exhibit known biological activities that have found uses in a wide array of research fields, especially cancer and neuroscience. These products include protein kinase inhibitors, ion channel modulators, and activators.
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