Description
PaxillineisaneuroactivemycotoxininitiallyproducedbyspeciesofPenicillumandAspergillus.Invitroandinvivo,paxillineinhibitsCa2+/voltage-sensitiveK+(BK)channels.Paxillinealsocompetitivelyinhibitssarco/endoplasmicreticulumCa2+ATPase(SERCA),preventingCa2+releaseandphosphoenzymeformation.
References
BorchertGH,HlaváčkováM,KolářF.PharmacologicalactivationofmitochondrialBK(Ca)channelsprotectsisolatedcardiomyocytesagainstsimulatedreperfusion-inducedinjury.ExpBiolMed(Maywood).2013Feb;238(2):233-41.PMID:23576804.
BilmenJG,WoottonLL,MichelangeliF.Themechanismofinhibitionofthesarco/endoplasmicreticulumCa2+ATPasebypaxilline.ArchBiochemBiophys.2002Oct1;406(1):55-64.PMID:12234490.