LKT/PROTOPANAXADIOL/P6957/25 mg,LKT Labs,,LKT Labs,lktlabs,+,,Array.Array.Array蚂蚁淘厂家直采.

ProductIDP6957

CasNo.7755-01-3

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

ProtopanaxADIolisatriterpenesapogeninoriginallyfoundinspeciesofPanax(ginseng)thatexhibitsanticancer,neuromodulatory,neuroprotective,andantioxidativeactivities.ProtopanaxadiolpreventsbreakdownofvitaminD3andactsasanantagoNISTatGABA-Areceptors.Protopanaxadiolalsoinhibitsproliferationofcolorectalcancercellsandinducesmitochondria-andcaspase-dependentapoptosisinlungadenocarcinomacellsbydecreasingthemitochondrialmembranepotentialandincreasingreleaseofcytochromeC,activationofcaspases3and9,andcleavageofPARP.Inanimalmodelsofcerebralischemia,protopanaxadiolincreasesactivityofsuperoxidedismutaseandNa+/K+ATPases,stimulatesexpressionofBcl-2,anddecreasesinfarctsizeandneurologicaldeficits.

ProductInfo

CasNo.	7755-01-3
Purity	≥98%
Formula	C₃₀H₅₂O₃
FormulaWt.	460.73
IUPACName	(3S,8R,9R,10R,12R,13R,14S,17S)-17-[(2R)-2-hydroxy-6-methylhept-5-en-2-yl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,12-diol
Appearance	WhitePowder

ShippingandStorage

StoreTemp	4°C
ShipTemp	Ambient

Downloads

MSDS	P6957MSDSPDF
InfoSheet	P6957InfoSheetPDF

References

DebS,ChinMY,AdomatH,etal.Ginsenoside-mediatedblockadeof1α,25-dihydroxyvitaminD3inactivationinhumanliverandintestineinvitro.JSteroidBiochemMolBiol.2014May;141:94-103.PMID:24486455.

XuH,YuX,QuS,etal.ProtectiveeffectofPanaxquinquefolium20(S)-protopanaxadiolsaponins,isolatedfromPanaquinquefolium,onpermanentfocalcerebralischemicinjuryinrats.ExpTherMed.2014Jan;7(1):165-170.PMID:24348784.

ZhengY,NanH,HaoM,etal.Antiproliferativeeffectsofprotopanaxadiolginsenosidesonhumancolorectalcancercells.BiomedRep.2013Jul;1(4):555-558.PMID:24648985.

ZhangYL,ZhangR,XuHL,etal.20(S)-protopanaxadioltriggersmitochondrial-mediatedapoptosisinhumanlungadenocarcinomaA549cellsviainhibitingthePI3K/Aktsignalingpathway.AmJChinMed.2013;41(5):1137-52.PMID:24117074.

LeeBH,ChoiSH,ShinTJ,etal.EffectsofGinsenosideMetabolitesonGABAAReceptor-MediatedIonCurrents.JGinsengRes.2012Jan;36(1):55-60.PMID:23717104.

品牌	货号	名称	规格
LKT Labs	444912-48-5	(2-iodo-5-nitrophenyl)-[1-[(1-methylpiperidin-2-yl)methyl]indol-3-yl]methanone	1mg 5mg 25mg
LKT Labs	294646-77-8	(R)-CR8	1mg 5mg
LKT Labs	2377-31-3	(Z)-1,-BIS(2-METHOXY-5-(TRIFLUOROMETHYL)PHENYL)DIAZENE OXIDE	1mg 5mg 25mg