PenicillinGisahydrophobicβ-lactamantibioticthatdisplaysantibacterialefficacyagainstgrampositivebacteria.PenicillinGismoreactivethanpenicillinVagainstgramnegativebacteriabutexhibitspoororalabsorptionkineticsandmustbeadmiNISTeredbyparenteralinjection.PenicillinGinhibitscellwallsynthesisanddoesnotdisplayeffectiveinhibitionofβ-lactamase-producingbacteria.PenicillinGmayinduceopenchannelorcompetitiveblockofneuromuscularnicotinicacetylcholinereceptors(nAChRs).
| CasNo. | 6130-64-9 |
|---|---|
| Purity | ≥98% |
| Formula | C29H38N4O6S•H2O |
| FormulaWt. | 588.73 |
| ChemicalName | (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-[(phenoxyacetyl)-amino]-4-Thia-1-azABIcyclo[3.2.0]heptane-2-carboxylicacidwith2-(diethylamino)ethyl4-aminobenzoate(1:1)monohydrate |
| IUPACName | 2-(diethylamino)ethyl4-aminobenzoate;(2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid;hydrate |
| Synonym | BenzylpenicillinProcainesalt;Abbocillin;Duracillin;Pfizerpen-AS |
| MeltingPoint | 106-110°C(dec) |
| Solubility | Solubleatabout28oCin:water(6.8mg/mL),methanol(>20mg/mL),ethanol(33mg/mL),andisopropanol(6.5mg/mL). |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | P1852MSDSPDF |
|---|---|
| InfoSheet | P1852InfoSheetPDF |
SunS,SelmerM,AnderssonDI.Resistancetoβ-lactamantibioticsconferredbypointmutationsinpenicillin-bindingproteinsPBP3,PBP4andPBP6inSalmonellaenterica.PLoSOne.2014May8;9(5):e97202.PMID:24810745.
SchlesingerF,KrampflK,HaeselerG,etal.CompetitiveandopenchannelblockofrecombinantnAChRchannelsbydifferentantibiotics.NeuromusculDisord.2004May;14(5):307-12.PMID:15099589.
DemainAL.Productionofbeta-lactamantibioticsanditsregulation.ProcNatlSciCouncRepubChinaB.1991Oct;15(4):251-65.PMID:1815263.
BärH,ZarnackJ.Molecular-BIOLOGicalbasesofthemechanismofactionofpenicillinsandcephasporins.Pharmazie.1970Jan1;25(1):10-22.PMID:4987180.
LKT Labs
LKT实验室是一家专注于小分子的合成、纯化和分离的生化供应公司，用于研究应用。它的产品系列展示了已知的生物活性，在广泛的研究领域，特别是癌症和神经科学中得到了广泛的应用。这些产品包括蛋白激酶抑制剂、离子通道调节剂和激活剂。
LKT Laboratories is a biochemical supply company focused on the synthesis, purification, and isolation of small molecules for research applications. Its range of products exhibit known biological activities that have found uses in a wide array of research fields, especially cancer and neuroscience. These products include protein kinase inhibitors, ion channel modulators, and activators.
|
品牌 |
货号 |
名称 |
规格 |
|
LKT Labs |
444912-48-5 |
(2-iodo-5-nitrophenyl)-[1-[(1-methylpiperidin-2-yl)methyl]indol-3-yl]methanone |
1mg 5mg 25mg |
|
LKT Labs |
294646-77-8 |
(R)-CR8 |
1mg 5mg |
|
LKT Labs |
2377-31-3 |
(Z)-1,-BIS(2-METHOXY-5-(TRIFLUOROMETHYL)PHENYL)DIAZENE OXIDE |
1mg 5mg 25mg |
