Description
Mevinolin (lovastatin) is a synthetic statin that is also produced by oyster mushrooms and some varieties of rice. Lovastatin inhibits HMG-CoA reductase, preventing cholesterol synthesis; it exhibits anti-hyperlipidemic, anticancer, and antiviral activities. In vitro, lovastatin inhibits proliferation of lymphoma cells, decreasing expression of ROS and transient receptor potential canonical 6 (TRPC6) channels. Additionally, lovastatin inhibits coxsackievirus replication, decreasing expression of coxsackie and adenovirus receptors and preventing viral entry.
References
Song X, Liu BC, Lu XY, et al. Lovastatin inhibits human B lymphoma cell proliferation by reducing intracellular ROS and TRPC6 expression.
Biochim Biophys Acta. 2014 May;1843(5):894-901. PMID: 24518247.
Werner B, Dittmann S, Funke C, et al. Effect of lovastatin on coxsackievirus B3 infection in human endothelial cells. Inflamm Res. 2014 Apr;63(4):267-76. PMID: 24316867.
Gunde-Cimerman N, Cimerman A. Pleurotus fruiting bodies contain the inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase-lovastatin. Exp Mycol. 1995 Mar;19(1):1-6. PMID: 7614366.
Alberts AW. Discovery, biochemistry and biology of lovastatin. Am J Cardiol. 1988 Nov 11;62(15):10J-15J. PMID: 3055919.
