Description
C-peptideisanendogenouspeptidethatconnectstheAandBchainsofinsulinintheproinsulinform.C-peptidebindscellsurfaces,activatingCa2+-dependentsignalingpathways.Inanimalmodelsofdiabetes,C-peptideimprovesNa+/K+ATPaseactivity,improvingneuropathysymptoms,andpreventsglomerularpathology,improvingkidneyfunction.
References
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SamnegårdB,JacobsonSH,JaremkoG,etal.EffectsofC-peptideonglomerularandrenalsizeandrenalfunctionindiabeticrats.KidneyInt.2001Oct;60(4):1258-65.PMID:11576340.
SimaAA,ZhangW,SugimotoK,etal.C-peptidepreventsandimproveschronicTypeIdiabeticpolyneuropathyintheBB/Worrat.Diabetologia.2001Jul;44(7):889-97.PMID:11508275.