Gastrin-releasing peptide (GRP) is an endogenous bombesin-like peptide that stimulates the release of gastrin by binding GRP receptors; it is involved in feeding behavior (acting as an anorexigenic), circadian rhythms, and stress signaling. GRP induces scratching behavior in vivo and exhibits pro-angiogenic activity in cancer models, inducing expression of IL-8 in a hepatocyte growth factor-dependent manner in gastric cancer cells.
| Cas No. | 93755-85-2 |
|---|---|
| Purity | ≥95% |
| Formula | C130H204N38O31S2 |
| Formula Wt. | 2859.40 |
| Synonym | GRP |
| Solubility | Soluble in water. |
| Appearance | White to off-white Powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | G0181 Info Sheet PDF |
|---|
Kallingal GJ, Mintz EM. Site-specific effects of gastrin-releasing peptide in the suprachiasmatic nucleus. Eur J Neurosci. 2014 Feb;39(4):630-9. PMID: 24528136.
Lee KH, Koh SA, Kim JR. Hepatocyte growth factor-mediated gastrin-releasing peptide induces IL-8 expression through Ets-1 in gastric cancer cells. Oncol Res. 2013;20(9):393-402. PMID: 23924923.
Sukhtankar DD, Ko MC. Physiological function of gastrin-releasing peptide and neuromedin B receptors in regulating itch scratching behavior in the spinal cord of mice. PLoS One. 2013 Jun 24;8(6):e67422. PMID: 23826298.
Merali Z, McIntosh J, Anisman H. Role of bombesin-related peptides in the control of food intake. Neuropeptides. 1999 Oct;33(5):376-86. PMID: 10657515.
LKT Labs
LKT实验室是一家专注于小分子的合成、纯化和分离的生化供应公司，用于研究应用。它的产品系列展示了已知的生物活性，在广泛的研究领域，特别是癌症和神经科学中得到了广泛的应用。这些产品包括蛋白激酶抑制剂、离子通道调节剂和激活剂。
LKT Laboratories is a biochemical supply company focused on the synthesis, purification, and isolation of small molecules for research applications. Its range of products exhibit known biological activities that have found uses in a wide array of research fields, especially cancer and neuroscience. These products include protein kinase inhibitors, ion channel modulators, and activators.
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规格 |
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LKT Labs |
444912-48-5 |
(2-iodo-5-nitrophenyl)-[1-[(1-methylpiperidin-2-yl)methyl]indol-3-yl]methanone |
1mg 5mg 25mg |
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LKT Labs |
294646-77-8 |
(R)-CR8 |
1mg 5mg |
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LKT Labs |
2377-31-3 |
(Z)-1,-BIS(2-METHOXY-5-(TRIFLUOROMETHYL)PHENYL)DIAZENE OXIDE |
1mg 5mg 25mg |
