Doxazosin is a quinazoline α1-adrenergic receptor inhibitor that exhibits antihypertensive and vasodilatory activities. Doxazosin is clinically used to treat hypertension and benign prostatic hyperplasia. Doxazosin induces Fas-mediated apoptosis in benign and malignant prostate cells.
| Cas No. | 77883-43-3 |
|---|---|
| Purity | ≥98% |
| Formula | C23H25N5O5 • CH3SO3H |
| Formula Wt. | 547.59 |
| Chemical Name | 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(2,3- dihydro-1,4-benzodioxan-2-yl)carbonyl)piperazine methanesulfonate |
| IUPAC Name | [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(2,3-dihydro-1,4-benzodioxin-3-yl)methanone;methanesulfonic acid |
| Synonym | Doxazosin Methanesulfonate; Alfadil; Benur; Cardular; Carduran; Normothen; Supressin; Zoxan |
| Melting Point | 275-277°C |
| Solubility | Slightly soluble in water. |
| Appearance | White or off-white Crystalline Powder |
| Store Temp | Ambient |
|---|---|
| Ship Temp | Ambient |
| MSDS | D5690 MSDS PDF |
|---|---|
| Info Sheet | D5690 Info Sheet PDF |
Shannon R, Chaudhry M. Effect of alpha1-adrenergic receptors in cardiac pathophysiology. Am Heart J. 2006 Nov;152(5):842-50. PMID: 17070143.
Garrison JB, Kyprianou N. Doxazosin induces apoptosis of benign and malignant prostate cells via a death receptor-mediated pathway. Cancer Res. 2006 Jan 1;66(1):464-72. PMID: 16397262.
Kyprianou N. Doxazosin and terazosin suppress prostate growth by inducing apoptosis: clinical significance. J Urol. 2003 Apr;169(4):1520-5. PMID: 12629407.
LKT Labs
LKT实验室是一家专注于小分子的合成、纯化和分离的生化供应公司，用于研究应用。它的产品系列展示了已知的生物活性，在广泛的研究领域，特别是癌症和神经科学中得到了广泛的应用。这些产品包括蛋白激酶抑制剂、离子通道调节剂和激活剂。
LKT Laboratories is a biochemical supply company focused on the synthesis, purification, and isolation of small molecules for research applications. Its range of products exhibit known biological activities that have found uses in a wide array of research fields, especially cancer and neuroscience. These products include protein kinase inhibitors, ion channel modulators, and activators.
|
品牌 |
货号 |
名称 |
规格 |
|
LKT Labs |
444912-48-5 |
(2-iodo-5-nitrophenyl)-[1-[(1-methylpiperidin-2-yl)methyl]indol-3-yl]methanone |
1mg 5mg 25mg |
|
LKT Labs |
294646-77-8 |
(R)-CR8 |
1mg 5mg |
|
LKT Labs |
2377-31-3 |
(Z)-1,-BIS(2-METHOXY-5-(TRIFLUOROMETHYL)PHENYL)DIAZENE OXIDE |
1mg 5mg 25mg |
