Description
Dantrolene is a hydantoin derivative that inhibits the ryanodine receptor (RyR), preventing mitochondrial Ca2+ uptake. Dantrolene also inhibits L-type Ca(V)1.1 Ca2+ channels and is clinically used to treat malignant hyperthermia. Dantrolene also exhibits cardioprotective activity, decreases apoptosis and TNF-α levels and increases IL-10 levels in various animal models of ischemia/reperfusion.
References
Jakob R, Beutner G, Sharma VK, et al. Molecular and functional identification of a mitochondrial ryanodine receptor in neurons. Neurosci Lett. 2014 May 23. [Epub ahead of print]. PMID: 24861510.
Bannister RA. Dantrolene-induced inhibition of skeletal L-type Ca2+ current requires RyR1 expression. Biomed Res Int. 2013;2013:390493. PMID: 23509717.
Boys JA, Toledo AH, Anaya-Prado R, et al. Effects of dantrolene on ischemia-reperfusion injury in animal models: a review of outcomes in heart, brain, liver, and kidney. J Investig Med. 2010 Oct;58(7):875-82. PMID: 20517166.