LKT/PAC-1/P004080/5 mg,LKT Labs,,LKT Labs,lktlabs,+,,Array.Array.Array蚂蚁淘厂家直采.

ProductIDP004080

CasNo.315183-21-2

Purity≥98%

Description
ProductInfo
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Description

PAC-1(ProcaspaseActivatingCompound1)hasbeenidentifiedthroughhigh-throughputscreeningasacompoundthatmayenhancetheenzymaticactivityofprocaspase-3invitro.Procaspase-3maybeusefulasananticancerstrategyduetoitslowfrequencyofmutationsincancerandexpressionofitsenzymeinseveraltypesofcancers.PAC-1convertsprocaspase-3toactivecaspase-3invitrobychelatingzincionsandtherebyinducingcelldeathinthetumorcells.Inmultiplecancercelllines,PAC-1wasshowntotriggerendoplasmicreticulumstresssignalingandinduceautophagyandmitochondria-mediatedapotosis.

ProductInfo

CasNo.	315183-21-2
Purity	≥98%
Formula	C₂₃H₂₈N₄O₂
FormulaWt.	392.50
ChemicalName	N"-[(6-oxo-5-prop-2-enyl-1-cyclohexa-2,4-dienylidene)methyl]-2-[4-(phenylmethyl)-1-piperazinyl]acetohydrazide
IUPACName	N"-[(Z)-(3-Allyl-2-hydroxyphenyl)methylene]-2-(4-benzyl-1-piperazinyl)acetohydrazide
Synonym	(4-Benzylpiperazino)aceticacid(3-allyl-2-hyroxybenzylidene)hydrazide,1-Piperazineaceticacid,2-(phenylmethyl)-,[[2-hydroxy-3-(2-propenyl)phenyl]methylene]hyrrazide

ShippingandStorage

StoreTemp	4°C
ShipTemp	Ambient

Downloads

InfoSheet	P004080InfoSheetPDF

References

SarkarA,BalakrishnanK,ChenJ,etal.MolecularevidenceofZnchelationoftheprocaspaseactivatingcompoundB-PAC-1inBcelllymphoma.Oncotarget.2016Jan19;7(3):3461-3476.PMID:26658105.

RothHS,HergenrotherPJ.Derivativesofprocaspase-activatingcompound1(PAC-1)andtheiranticanceractivities.CurrMedChem.2016;23(3):201-241.PMID:26630918.

SeerviM,SobhanPK,JosephJ,etal.ERO1alpha-dependentendoplasmicreticulum-mitochondrialcalciumfluxcontributestoERstressandmitochondrialpermeABIlizationbyprocaspase-activatingcompound-1(PAC-1).CellDeathDis.2013Dec19;4:e968.PMID:24357799.

LucasPW,SchmitJM,PetersonQP,etal.PharmacokineticsandderivationofananticancerdosingregimenforPAC-1,apreferentialsmallmoleculeactivatorofprocaspase-3,inhealthydogs.InvestNewDrugs.2011Oct;29(5):901-911.PMID:20499133.

PetersonQP,GoodeDR,WestDC,etal.PAC-1activatesprocaspase-3invitrothroughreliefofzinc-mediatedinhibition.JMolBiol.2009Apr24;388(1):144-158.PMID:19281821.

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