Nexturastat A is an inhibitor of histone deacetylase 6 (HDAC 6) that exhibits immunomodulatory and anticancer chemotherapeutic activities. In melanoma cells, nexturastat A inhibits cell proliferation, upregulates expression of MHC class I, and induces G1 phase cell cycle arrest without stimulating apoptosis. In animal models of melanoma, this compound delays tumor growth.
| Cas No. | 1403783-31-2 |
|---|---|
| Purity | ≥98% |
| Formula | C19H23N3O3 |
| Formula Wt. | 341.41 |
| IUPAC Name | 4-{[Butyl(phenylcarbamoyl)amino]methyl}-N-hydroxybenzamide |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | N1894 Info Sheet PDF |
|---|
Woan KV, Lienlaf M, Perez-Villaroel P, et al. Targeting histone deacetylase 6 mediates a dual anti-melanoma effect: Enhanced antitumor immunity and impaired cell proliferation. Mol Oncol. 2015 Apr 24. [Epub ahead of print]. PMID: 25957812.
LKT Labs
LKT实验室是一家专注于小分子的合成、纯化和分离的生化供应公司，用于研究应用。它的产品系列展示了已知的生物活性，在广泛的研究领域，特别是癌症和神经科学中得到了广泛的应用。这些产品包括蛋白激酶抑制剂、离子通道调节剂和激活剂。
LKT Laboratories is a biochemical supply company focused on the synthesis, purification, and isolation of small molecules for research applications. Its range of products exhibit known biological activities that have found uses in a wide array of research fields, especially cancer and neuroscience. These products include protein kinase inhibitors, ion channel modulators, and activators.
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品牌 |
货号 |
名称 |
规格 |
|
LKT Labs |
444912-48-5 |
(2-iodo-5-nitrophenyl)-[1-[(1-methylpiperidin-2-yl)methyl]indol-3-yl]methanone |
1mg 5mg 25mg |
|
LKT Labs |
294646-77-8 |
(R)-CR8 |
1mg 5mg |
|
LKT Labs |
2377-31-3 |
(Z)-1,-BIS(2-METHOXY-5-(TRIFLUOROMETHYL)PHENYL)DIAZENE OXIDE |
1mg 5mg 25mg |
