Kartogeninstimulateschondrogenicdifferentiationofbone-derivedmesenchymalstemcells(BMSCs)toimproverepairoffull-thicknesscartilagedefectsinmicrofracturemodels.Kartogeninalsoinducesformationofcartilage-liketissueandenhanceswoundhealinginanimalmodels.Thiscompoundmaydisplaypro-fibroticactivity.Kartogeninincreasescartilagenoduleformation,digitcartilaginousanlageelongation,synovialjointformation,andtendonmaturation.
| CasNo. | 4727-31-5 |
|---|---|
| Purity | ≥98% |
| Formula | C20H15NO3 |
| FormulaWt. | 317.34 |
| IUPACName | 2-(4-Biphenylylcarbamoyl)benzoicacid |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | K0271InfoSheetPDF |
|---|
LiuC,MaX,LiT,etal.Kartogenin,transforminggrowthfactor-β1andbonemorphogeneticprotein-7coordinatelyenhancelubricinaccumulationinbone-derivedmesenchymalstemcells.CellBiolInt.2015Apr9.[Epubaheadofprint].PMID:25857705.
XuX,ShiD,ShenY,etal.Full-thicknesscartilagedefectsarerepairedviaamicrofracturetechniqueandintraarticularinjectionofthesmall-moleculecompoundkartogenin.ArthritisResTher.2015Feb2;17:20.PMID:25641548.
ZhangJ,WangJH.Kartogenininducescartilage-liketissueformationintendon-bonejunction.BoneRes.2014;2.pii:14008.PMID:25419468.
DeckerRS,KoyamaE,Enomoto-IwamotoM,etal.MouselimbskeletalgrowthandsynovialjointdevelopmentarecoordinatelyenhancedbyKartogenin.DevBiol.2014Nov15;395(2):255-67.PMID:25238962.
LKT Labs
LKT实验室是一家专注于小分子的合成、纯化和分离的生化供应公司，用于研究应用。它的产品系列展示了已知的生物活性，在广泛的研究领域，特别是癌症和神经科学中得到了广泛的应用。这些产品包括蛋白激酶抑制剂、离子通道调节剂和激活剂。
LKT Laboratories is a biochemical supply company focused on the synthesis, purification, and isolation of small molecules for research applications. Its range of products exhibit known biological activities that have found uses in a wide array of research fields, especially cancer and neuroscience. These products include protein kinase inhibitors, ion channel modulators, and activators.
|
品牌 |
货号 |
名称 |
规格 |
|
LKT Labs |
444912-48-5 |
(2-iodo-5-nitrophenyl)-[1-[(1-methylpiperidin-2-yl)methyl]indol-3-yl]methanone |
1mg 5mg 25mg |
|
LKT Labs |
294646-77-8 |
(R)-CR8 |
1mg 5mg |
|
LKT Labs |
2377-31-3 |
(Z)-1,-BIS(2-METHOXY-5-(TRIFLUOROMETHYL)PHENYL)DIAZENE OXIDE |
1mg 5mg 25mg |
