Description
Indoximodisaninhibitorofindoleamine2,3dioxygenase,whichplaysaroleinimmuneregulation.IndoximodhasbeenfoundtoenhanceinflammatorycytokinesIL-1betaandIL-6expressioninhumancornealepithelialcellsexposedtoinactivatedA.fumigatusspores.Indoximodhasalsobeenfoundasametaboliteintomatoplantsexposedtofungiorbacteria.
References
SolimanHH,MintonSE,HanHS,etal.AphaseIstudyofindoximodinpatientswithadvancedmalignancies.Oncotarget.2016Apr19;7(16):22928-22938.PMID:27008709
JiangN,ZhaoG,LinJ,etal.Indoleamine2,3-dioxygenaseisinvolvedintheinflammationresponseofcornealepithelialcellstoaspergillusfumigatusinfections.PLoSOne.2015Sep11;10(9):e0137423.PMID:26361229
CamanesG,ScalschiL,VicedoB,etal.AnuntargetedglobalmetabolomicanalysisrevealsthebiochemicalchangesunderlyingbasalresistanceandpriminginSolanumlycopersicum,andidentifies1-methyltryptophanasametaboliteinvolvedinplantresponsestoBotrytiscinereaandPseudomonassyringae.PlantJ.2015Oct;84(1):125-139.PMID:26270176