Trimebutine exhibits antibacterial and gastrointestinal motility modulating activities; it is clinically used to treat irritable bowel syndrome (IBS). Trimebutine displays antibiotic activity against Escherichia and Pseudomonas. This compound enhances gastrointestinal muscle contractions by inhibiting L-type Ca2+ channels and decreasing Ca2+-sensitive (BK) K+ currents and may also act as an agonist at opioid receptors.
| Cas No. | 39133-31-8 |
|---|---|
| Purity | ≥97% |
| Formula | C22H29NO5 |
| Formula Wt. | 387.47 |
| Chemical Name | Benzoic acid, 3,4,5-trimethoxy-, 2-(dimethylamino)-2-phenylbutyl ester |
| IUPAC Name | [2-(dimethylamino)-2-phenylbutyl] 3,4,5-trimethoxybenzoate |
| Synonym | EINECS 254-309-2 |
| Melting Point | 78-80°C |
| Solubility | Soluble in methylene chloride. |
| Appearance | White Crystal Powder |
| Store Temp | Ambient |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | T6935 Info Sheet PDF |
|---|
Kountouras J, Sofianou D, Gavalas E, et al. Trimebutine as a potential antimicrobial agent: a preliminary in vitro approach. Hippokratia. 2012 Oct;16(4):347-9. PMID: 23935315.
Tan W, Zhang H, Luo HS, et al. Effects of trimebutine maleate on colonic motility through Ca²+-activated K+ channels and L-type Ca²+ channels. Arch Pharm Res. 2011 Jun;34(6):979-85. PMID: 21725819.
LKT Labs
LKT实验室是一家专注于小分子的合成、纯化和分离的生化供应公司，用于研究应用。它的产品系列展示了已知的生物活性，在广泛的研究领域，特别是癌症和神经科学中得到了广泛的应用。这些产品包括蛋白激酶抑制剂、离子通道调节剂和激活剂。
LKT Laboratories is a biochemical supply company focused on the synthesis, purification, and isolation of small molecules for research applications. Its range of products exhibit known biological activities that have found uses in a wide array of research fields, especially cancer and neuroscience. These products include protein kinase inhibitors, ion channel modulators, and activators.
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品牌 |
货号 |
名称 |
规格 |
|
LKT Labs |
444912-48-5 |
(2-iodo-5-nitrophenyl)-[1-[(1-methylpiperidin-2-yl)methyl]indol-3-yl]methanone |
1mg 5mg 25mg |
|
LKT Labs |
294646-77-8 |
(R)-CR8 |
1mg 5mg |
|
LKT Labs |
2377-31-3 |
(Z)-1,-BIS(2-METHOXY-5-(TRIFLUOROMETHYL)PHENYL)DIAZENE OXIDE |
1mg 5mg 25mg |
