Spironolactoneisadiureticthatinhibitsaldosteronereceptors,mineralocorticoidreceptors,androgenreceptors,andendothelialNa+channels(ENaCs).Spironolactoneexhibitsantihypertensiveactivityandisclinicallyusedtotreatheartfailure.Spironolactonemayinhibitvoltage-gatedCa2+channels.
| CasNo. | 52-01-7 |
|---|---|
| Purity | ≥97% |
| Formula | C24H32O4S |
| FormulaWt. | 416.57 |
| ChemicalName | (7α,17α)-7-(Acetylthio)-17-hydroxy-3-oxopregn-4-ene-21-carboxylicacidγ-lactone |
| IUPACName | S-[(7R,8R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5"-dioxospiro[2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-17,2"-oxolane]-7-yl]ethanethioate |
| Synonym | Spirolactone;Spiroctan;Aldactone |
| MeltingPoint | 134-135°C(lit.) |
| Solubility | Solubleinorganicsolvents.Practicallyinsolubleinwater. |
| Appearance | Off-WhiteCrystalPowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | S6235InfoSheetPDF |
|---|
YancyCW,JessupM,BozkurtB,etal.2013ACCF/AHAguidelineforthemanagementofheartfailure:areportoftheAmericanCollegeofCardiologyFoundation/AmericanHeartAssociationTaskForceonPracticeGuidelines.JAmCollCardiol.2013Oct15;62(16):e147-239.PMID:23747642.
MannSJ,ParikhNS.AsimplifiedmechaNISTicalgorithmfortreatingresistanthypertension:efficacyinaretrospectivestudy.JClinHypertens(Greenwich).2012Apr;14(4):191-7.PMID:22458739.
NappiJM,SiegA.Aldosteroneandaldosteronereceptorantagonistsinpatientswithchronicheartfailure.VascHealthRiskManag.2011;7:353-63.PMID:21731887.
LKT Labs
LKT实验室是一家专注于小分子的合成、纯化和分离的生化供应公司，用于研究应用。它的产品系列展示了已知的生物活性，在广泛的研究领域，特别是癌症和神经科学中得到了广泛的应用。这些产品包括蛋白激酶抑制剂、离子通道调节剂和激活剂。
LKT Laboratories is a biochemical supply company focused on the synthesis, purification, and isolation of small molecules for research applications. Its range of products exhibit known biological activities that have found uses in a wide array of research fields, especially cancer and neuroscience. These products include protein kinase inhibitors, ion channel modulators, and activators.
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品牌 |
货号 |
名称 |
规格 |
|
LKT Labs |
444912-48-5 |
(2-iodo-5-nitrophenyl)-[1-[(1-methylpiperidin-2-yl)methyl]indol-3-yl]methanone |
1mg 5mg 25mg |
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LKT Labs |
294646-77-8 |
(R)-CR8 |
1mg 5mg |
|
LKT Labs |
2377-31-3 |
(Z)-1,-BIS(2-METHOXY-5-(TRIFLUOROMETHYL)PHENYL)DIAZENE OXIDE |
1mg 5mg 25mg |
