Ikarugamycin is an antibiotic initially produced by species of Streptomyces that exhibits antibacterial, anti-protozoal, and anticancer activities. Ikarugamycin prevents formation of the bacterial 70S ribosomal subunit, inhibiting protein translation. In vitro, ikarugamycin inhibits CCP-dependent phagocytosis, preventing PMA-induced downregulation of CD4. Additionally, ikarugamycin inhibits uptake of oxidized LDL, preventing accumulation of cholesterol ester in macrophages.
| Cas No. | 36531-78-9 |
|---|---|
| Purity | ≥98% |
| Formula | C29H38N2O4 |
| Formula Wt. | 478.62 |
| Appearance | White Crystal Powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | I4000 MSDS PDF |
|---|---|
| Info Sheet | I4000 Info Sheet PDF |
Popescu R, Heiss EH, Ferk F, et al. Ikarugamycin induces DNA damage, intracellular calcium increase, p38 MAP kinase activation and apoptosis in HL-60 human promyelocytic leukemia cells. Mutat Res. 2011 May 10;709-710:60-6. PMID: 21392513.
Luo T, Fredericksen BL, Hasumi K, et al. Human immunodeficiency virus type 1 Nef-induced CD4 cell surface downregulation is inhibited by ikarugamycin. J Virol. 2001 Mar;75(5):2488-92. PMID: 11160755.
Hasumi K, Shinohara C, Naganuma S, et al. Inhibition of the uptake of oxidized low-density lipoprotein in macrophage J774 by the antibiotic ikarugamycin. Eur J Biochem. 1992 Apr 15;205(2):841-6. PMID: 1572375.
Jomon K, Kuroda Y, Ajisaka M, et al. A new antibiotic, ikarugamycin. J Antibiot (Tokyo). 1972 May;25(5):271-80. PMID: 4625358.
LKT Labs
LKT实验室是一家专注于小分子的合成、纯化和分离的生化供应公司，用于研究应用。它的产品系列展示了已知的生物活性，在广泛的研究领域，特别是癌症和神经科学中得到了广泛的应用。这些产品包括蛋白激酶抑制剂、离子通道调节剂和激活剂。
LKT Laboratories is a biochemical supply company focused on the synthesis, purification, and isolation of small molecules for research applications. Its range of products exhibit known biological activities that have found uses in a wide array of research fields, especially cancer and neuroscience. These products include protein kinase inhibitors, ion channel modulators, and activators.
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品牌 |
货号 |
名称 |
规格 |
|
LKT Labs |
444912-48-5 |
(2-iodo-5-nitrophenyl)-[1-[(1-methylpiperidin-2-yl)methyl]indol-3-yl]methanone |
1mg 5mg 25mg |
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LKT Labs |
294646-77-8 |
(R)-CR8 |
1mg 5mg |
|
LKT Labs |
2377-31-3 |
(Z)-1,-BIS(2-METHOXY-5-(TRIFLUOROMETHYL)PHENYL)DIAZENE OXIDE |
1mg 5mg 25mg |
