Pefloxacin is a synthetic third generation fluoroquinolone antibiotic. Pefloxacin displays antibacterial activity; it inhibits DNA gyrase and topoisomerase IV, suppressing DNA replication and transcription. Additionally, pefloxacin inhibits synthesis of penicillin-binding proteins, preventing bacterial cell wall formation. Pefloxacin exhibits moderate UV-induced phototoxicity.
| Cas No. | 149676-40-4 |
|---|---|
| Purity | ≥98% |
| Formula | C17H20FN3O3 • CH3SO3H • 2H2O |
| Formula Wt. | 465.50 |
| Chemical Name | 1-ethyl-6-fluoro-1,4-dihydro-7-(4-methyl-1- piperazinyl)-4-oxo-3-quinolinecarboxylic acid monomethanesulfonate |
| IUPAC Name | 1-ethyl-6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylicacid |
| Synonym | Pefloxacine mesylate; Peflacine; Peflox |
| Appearance | Almost White Crystalline Powder |
| Store Temp | Ambient |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | P1622 Info Sheet PDF |
|---|
Martínez LJ, Sik RH, Chignell CF. Fluoroquinolone antimicrobials: singlet oxygen, superoxide and phototoxicity. Photochem Photobiol. 1998 Apr;67(4):399-403. PMID: 9559584.
Grossato A, Fontana R. Synergy and mechanism of interaction between pefloxacin and penicillin G against enterococci. New Microbiol. 1997 Jul;20(3):221-5. PMID: 9258941.
Moreau NJ, Houot S, Joly-Guillou ML, et al. Characterisation of DNA gyrase and measurement of drug accumulation in clinical isolates of Acinetobacter baumannii resistant to fluoroquinolones. J Antimicrob Chemother. 1996 Dec;38(6):1079-83. PMID: 9023657.
LKT Labs
LKT实验室是一家专注于小分子的合成、纯化和分离的生化供应公司，用于研究应用。它的产品系列展示了已知的生物活性，在广泛的研究领域，特别是癌症和神经科学中得到了广泛的应用。这些产品包括蛋白激酶抑制剂、离子通道调节剂和激活剂。
LKT Laboratories is a biochemical supply company focused on the synthesis, purification, and isolation of small molecules for research applications. Its range of products exhibit known biological activities that have found uses in a wide array of research fields, especially cancer and neuroscience. These products include protein kinase inhibitors, ion channel modulators, and activators.
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品牌 |
货号 |
名称 |
规格 |
|
LKT Labs |
444912-48-5 |
(2-iodo-5-nitrophenyl)-[1-[(1-methylpiperidin-2-yl)methyl]indol-3-yl]methanone |
1mg 5mg 25mg |
|
LKT Labs |
294646-77-8 |
(R)-CR8 |
1mg 5mg |
|
LKT Labs |
2377-31-3 |
(Z)-1,-BIS(2-METHOXY-5-(TRIFLUOROMETHYL)PHENYL)DIAZENE OXIDE |
1mg 5mg 25mg |
